Fndc5^em1Cya
Endonuclease-mediated Allele Detail

Summary

• Symbol: Fndc5^em1Cya
• Name: fibronectin type III domain containing 5; endonuclease-mediated mutation 1, Cyagen Biosciences
• MGI ID: MGI:7256931
• Synonyms: Fndc5^em1Cgen
• Gene: Fndc5 Location: Chr4:129030672-129038386 bp, + strand Genetic Position: Chr4, 62.93 cM
• Alliance: Fndc5^em1Cya page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR/cas9 mediated recombination created a 984 bp deletion including exon 2. (J:322145)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fndc5 Mutation: 19 strains or lines available

References

• Original: J:322145 Li DJ, et al., NAD(+)-boosting therapy alleviates nonalcoholic fatty liver disease via stimulating a novel exerkine Fndc5/irisin. Theranostics. 2021;11(9):4381-4402
• All: 1 reference(s)