Stk11^tm1.2Mmw
Targeted Allele Detail

Summary

• Symbol: Stk11^tm1.2Mmw
• Name: serine/threonine kinase 11; targeted mutation 1.2, Monte Winslow
• MGI ID: MGI:7256714
• Synonyms: Lkb1^TR
• Gene: Stk11 Location: Chr10:79951637-79966516 bp, + strand Genetic Position: Chr10, 39.72 cM
• Alliance: Stk11^tm1.2Mmw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:321839
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: The targeting vector is designed to insert a cassette containing an inverted enhanced green fluorescent protein (EGFP) sequence, with a polyadenylation signal, downstream of exon 1. Specifically, the vector includes, from 5' to 3', an FRT-flanked neomycin resistance (neo) cassette, an inverted EGFP flanked by inward facing 2272loxP and 5171loxP sites and third FRT site inserted downstream of the floxed EGFP. Flp-mediated recombination removed the FRT-flanked neo cassette. Cre-mediated recombination reversed the cassette trapping expression. (J:321839)

Tumor Data

List all tumor models in MMHCdb carrying Stk11^tm1.2Mmw

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Stk11 Mutation: 35 strains or lines available

References

• Original: J:321839 Murray CW, et al., LKB1 drives stasis and C/EBP-mediated reprogramming to an alveolar type II fate in lung cancer. Nat Commun. 2022 Feb 28;13(1):1090
• All: 1 reference(s)