Suv39h2^em1Tyrb
Endonuclease-mediated Allele Detail

Summary

• Symbol: Suv39h2^em1Tyrb
• Name: suppressor of variegation 3-9 2; endonuclease-mediated mutation 1, Takeo Yoshikawa
• MGI ID: MGI:7256603
• Gene: Suv39h2 Location: Chr2:3456852-3476068 bp, - strand Genetic Position: Chr2, 1.95 cM, cytoband A
• Alliance: Suv39h2^em1Tyrb page

Mutation origin

• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR-targeting of exon 1 deleted 25 bp. (J:321945)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Suv39h2 Mutation: 23 strains or lines available

References

• Original: J:321945 Balan S, et al., A loss-of-function variant in SUV39H2 identified in autism-spectrum disorder causes altered H3K9 trimethylation and dysregulation of protocadherin beta-cluster genes in the developing brain. Mol Psychiatry. 2021 Dec;26(12):7550-7559
• All: 1 reference(s)