Txnip^tm1.1Jyos
Targeted Allele Detail

Summary

• Symbol: Txnip^tm1.1Jyos
• Name: thioredoxin interacting protein; targeted mutation 1.1, Jun Yoshioka
• MGI ID: MGI:7256567
• Synonyms: Txnip^{(loxP- exons2-8-loxP)C247S}
• Gene: Txnip Location: Chr3:96465273-96469173 bp, + strand Genetic Position: Chr3, 41.93 cM, cytoband F2.2
• Alliance: Txnip^tm1.1Jyos page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:322003
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutations: Insertion, Single point mutation
• Mutation details: Two loxP sites were introduced flanking exons 2 to 8 and another set of exons 2-8 containing a T to A change resulting in a cysteine to serine substitution at amino acid 247 (C247S) in exon 5 was incorporated after the second loxP site. In addition, a neomycin selection cassette flanked by self-deletion anchor sites was inserted upstream of the second loxP site and was removed in germ cells. (J:322003)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Txnip Mutation: 51 strains or lines available

References

• Original: J:322003 Nakayama Y, et al., Txnip C247S mutation protects the heart against acute myocardial infarction. J Mol Cell Cardiol. 2021 Jun;155:36-49
• All: 2 reference(s)