Mapt^{tm1.1(MAPT*P301L)Ins}
Targeted Allele Detail

Summary

• Symbol: Mapt^{tm1.1(MAPT*P301L)Ins}
• Name: microtubule-associated protein tau; targeted mutation 1.1, INSERM
• MGI ID: MGI:7256538
• Synonyms: tau KI
• Gene: Mapt Location: Chr11:104122216-104222916 bp, + strand Genetic Position: Chr11, 67.79 cM, cytoband E1
• Alliance: Mapt^{tm1.1(MAPT*P301L)Ins} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:321949
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: The targeting construct inserted into exon 1 of the mouse gene after the translation initiation codon a floxed transgene containing the human cDNA of isoform 1N4R mutated at P301L with a STOP codon and V5 epitope tag. Flp-mediated recombination removed the FRT-flanked neomycin resistance cassette at the 5' end of the transgene. (J:321949)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mapt Mutation: 453 strains or lines available

References

• Original: J:321949 Benderradji H, et al., Impaired Glucose Homeostasis in a Tau Knock-In Mouse Model. Front Mol Neurosci. 2022;15:841892
• All: 1 reference(s)