Trp53bp2^tm1.1Srin
Targeted Allele Detail

Summary

• Symbol: Trp53bp2^tm1.1Srin
• Name: transformation related protein 53 binding protein 2; targeted mutation 1.1, Shankar Srinivas
• MGI ID: MGI:7254967
• Synonyms: ASPP2^RAKA
• Gene: Trp53bp2 Location: Chr1:182236737-182289997 bp, + strand Genetic Position: Chr1, 84.93 cM
• Alliance: Trp53bp2^tm1.1Srin page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:321506
• Parent Cell Line: iTL BA1 (ES Cell)
• Strain of Origin: (C57BL/6NTac x 129S6/SvEvTac)F1

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutation: Nucleotide substitutions
• Mutation details: The targeting cassette inserted mutations that prevent the protein product from associating with protein phosphatase 1. Flp-mediated recombination removed the FRT-flanked neomycin resistance cassette. (J:321506)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trp53bp2 Mutation: 52 strains or lines available

References

• Original: J:321506 Royer C, et al., ASPP2 maintains the integrity of mechanically stressed pseudostratified epithelia during morphogenesis. Nat Commun. 2022 Feb 17;13(1):941
• All: 1 reference(s)