Opn4^{tm4.1(DTA)Saha}
Targeted Allele Detail

Summary

• Symbol: Opn4^{tm4.1(DTA)Saha}
• Name: opsin 4 (melanopsin); targeted mutation 4.1, Samer Hattar
• MGI ID: MGI:7254852
• Synonyms: Opn4^aDTA
• Gene: Opn4 Location: Chr14:34312575-34322099 bp, - strand Genetic Position: Chr14, 20.83 cM, cytoband B
• Alliance: Opn4^{tm4.1(DTA)Saha} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:101977
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutation: Intragenic deletion
• Mutation details: An attenuated diphtheria toxin A gene and loxP-flanked neo cassette were inserted immediately downstream of the start methionine codon replacing the coding region through part of exon 9. Expression of this allele results in the ablation of intrinsically photosensitive retinal ganglion cells. Flp-mediated recombination removed the FRT-flanked neo cassette. (J:134780)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Opn4 Mutation: 34 strains or lines available

Notes

The version of this allele that contains the neomycin selection cassette, Opn4^tm4(DTA)Saha, has been analyzed.

References

• Original: J:134780 Guler AD, et al., Melanopsin cells are the principal conduits for rod-cone input to non-image-forming vision. Nature. 2008 May 1;453(7191):102-5
• All: 2 reference(s)