C3^em1Hlee
Endonuclease-mediated Allele Detail

Summary

• Symbol: C3^em1Hlee
• Name: complement component 3; endonuclease-mediated mutation 1, Ho Lee
• MGI ID: MGI:6890375
• Gene: C3 Location: Chr17:57510970-57535136 bp, - strand Genetic Position: Chr17, 29.72 cM, cytoband E1-E3
• Alliance: C3^em1Hlee page

Mutation origin

• Strain of Origin: FVB/NHsd

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR-targeting of exon 2 deleted 11 bp resulting in a frameshift and premature termination. (J:321378)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any C3 Mutation: 100 strains or lines available

References

• Original: J:321378 Park JW, et al., Deficiency of complement component 3 may be linked to the development of constipation in FVB/N-C3(em1Hlee) /Korl mice. FASEB J. 2021 Jan;35(1):e21221
• All: 3 reference(s)