Ephb4^tm1.1Aztc
Targeted Allele Detail

Summary

• Symbol: Ephb4^tm1.1Aztc
• Name: Eph receptor B4; targeted mutation 1.1, Astrazeneca Transgenic Center
• MGI ID: MGI:6888272
• Synonyms: Ephb4^fl
• Gene: Ephb4 Location: Chr5:137348371-137372784 bp, + strand Genetic Position: Chr5, 76.38 cM
• Alliance: Ephb4^tm1.1Aztc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:237127
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6JOlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The targeting construct floxed exons 2 and 3. Flp-mediated recombination removed the FRT-flanked neomycin resistance cassette. (J:237127)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ephb4 Mutation: 43 strains or lines available

Notes

ES cell = AZX1 (C57BL/6JOlaHsd)

References

• Original: J:237127 Martin-Almedina S, et al., EPHB4 kinase-inactivating mutations cause autosomal dominant lymphatic-related hydrops fetalis. J Clin Invest. 2016 Aug 01;126(8):3080-8
• All: 5 reference(s)