Kcnj11^em1Zlu
Endonuclease-mediated Allele Detail

Summary

• Symbol: Kcnj11^em1Zlu
• Name: potassium inwardly rectifying channel, subfamily J, member 11; endonuclease-mediated mutation 1, Zhe Lu
• MGI ID: MGI:6888235
• Synonyms: ^EndomKir6.2^V108E
• Gene: Kcnj11 Location: Chr7:45746545-45750215 bp, - strand Genetic Position: Chr7, 29.66 cM
• Alliance: Kcnj11^em1Zlu page

Mutation origin

• Strain of Origin: FVB/N

Mutation description

• Allele Type: Endonuclease-mediated (Not Applicable)
• Mutation: Single point mutation
• Mutation details: CRISPR/Cas9 technology generated T to A change at position 323 resulting in a valine to glutamate substitution at residue 108 (V108E), generating a high SpTx1-sensitive mutant allele. SpTx1 is a Kir6.2-pore blocking venom toxin. (J:321749)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kcnj11 Mutation: 33 strains or lines available

References

• Original: J:321749 Ramu Y, et al., Blocking Kir6.2 channels with SpTx1 potentiates glucose-stimulated insulin secretion from murine pancreatic beta cells and lowers blood glucose in diabetic mice. Elife. 2022 Feb 25;11:e77026
• All: 1 reference(s)