Apoe^em5Smoc
Endonuclease-mediated Allele Detail

Summary

• Symbol: Apoe^em5Smoc
• Name: apolipoprotein E; endonuclease-mediated mutation 5, Shanghai Model Organisms Center
• MGI ID: MGI:6888202
• Gene: Apoe Location: Chr7:19430034-19433113 bp, - strand Genetic Position: Chr7, 9.94 cM
• Alliance: Apoe^em5Smoc page

Mutation origin

• Strain of Origin: C57BL/6JSmoc

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR-targeting deleted exons 2 through 4. (J:321539)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Apoe Mutation: 168 strains or lines available

References

• Original: J:321539 Yan P, et al., LARP7 ameliorates cellular senescence and aging by allosterically enhancing SIRT1 deacetylase activity. Cell Rep. 2021 Nov 23;37(8):110038
• All: 3 reference(s)