Alox12^em1Holi
Endonuclease-mediated Allele Detail

Summary

• Symbol: Alox12^em1Holi
• Name: arachidonate 12-lipoxygenase; endonuclease-mediated mutation 1, Hongliang Li
• MGI ID: MGI:6888162
• Gene: Alox12 Location: Chr11:70132283-70146179 bp, - strand Genetic Position: Chr11, 42.99 cM
• Alliance: Alox12^em1Holi page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR/Cas9 technology targeting exon 5 generated a knock-out allele. (J:281185)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Alox12 Mutation: 40 strains or lines available

References

• Original: J:281185 Zhang XJ, et al., An ALOX12-12-HETE-GPR31 signaling axis is a key mediator of hepatic ischemia-reperfusion injury. Nat Med. 2018 Jan;24(1):73-83
• All: 2 reference(s)