Ptprc^em1Smoc
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ptprc^em1Smoc
• Name: protein tyrosine phosphatase receptor type C; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
• MGI ID: MGI:6888155
• Synonyms: CD45.1, Ptprc^{em1(K302E)Smoc}
• Gene: Ptprc Location: Chr1:137990599-138103446 bp, - strand Genetic Position: Chr1, 60.73 cM
• Alliance: Ptprc^em1Smoc page

Mutation origin

• Strain of Origin: C57BL/6JSmoc

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Single point mutation
• Mutation details: CRISPR-targeting inserted the mutation causing an amino acid substitution of lysine with glutamic acid at position 302 (K302E). (J:321705)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ptprc Mutation: 211 strains or lines available

References

• Original: J:321705 Xu Y, et al., Induction of Foxp3 and activation of Tregs by HSP gp96 for treatment of autoimmune diseases. iScience. 2021 Dec 17;24(12):103445
• All: 5 reference(s)