Pycard^em1Baili
Endonuclease-mediated Allele Detail

Summary

• Symbol: Pycard^em1Baili
• Name: PYD and CARD domain containing; endonuclease-mediated mutation 1, Li Bai
• MGI ID: MGI:6887966
• Synonyms: Asc^C171A
• Gene: Pycard Location: Chr7:127590545-127593039 bp, - strand Genetic Position: Chr7, 69.88 cM, cytoband F4
• Alliance: Pycard^em1Baili page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Nucleotide substitutions
• Mutation details: CRISPR-targeting of exon 3 inserted the mutation that results in the amino acid substitution of cysteine with alanine at position 171 (C171A). (J:321627)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pycard Mutation: 16 strains or lines available

References

• Original: J:321627 Li S, et al., ASC deglutathionylation is a checkpoint for NLRP3 inflammasome activation. J Exp Med. 2021 Sep 6;218(9):e20202637
• All: 1 reference(s)