Lamp2^em1Onal
Endonuclease-mediated Allele Detail

Summary

• Symbol: Lamp2^em1Onal
• Name: lysosomal-associated membrane protein 2; endonuclease-mediated mutation 1, Melda Onal
• MGI ID: MGI:6887958
• Synonyms: L2ACgKO
• Gene: Lamp2 Location: ChrX:37490234-37545331 bp, - strand Genetic Position: ChrX, 22.67 cM
• Alliance: Lamp2^em1Onal page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Modified isoform(s))
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology deleted exons 9A and 9C. qRT-PCR indicates absence of Lamp2a and Lamp2c isoform transcripts in all tissues examined. Expression of the Lamp2b isoform is increased. (J:321670)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lamp2 Mutation: 14 strains or lines available

References

• Original: J:321670 Akel N, et al., Loss of chaperone-mediated autophagy is associated with low vertebral cancellous bone mass. Sci Rep. 2022 Feb 24;12(1):3134
• All: 1 reference(s)