Lmna^tm1.1Hjw
Targeted Allele Detail

Summary

• Symbol: Lmna^tm1.1Hjw
• Name: lamin A; targeted mutation 1.1, Howard J Worman
• MGI ID: MGI:6887957
• Synonyms: Lmna^L648R
• Gene: Lmna Location: Chr3:88388455-88413842 bp, - strand Genetic Position: Chr3, 38.84 cM
• Alliance: Lmna^tm1.1Hjw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:321636
• Parent Cell Line: KV1 (ES Cell)
• Strain of Origin: (C57BL/6J x 129S6/SvEvTac)F1

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutation: Single point mutation
• Mutation details: The targeting construct replaced exon 11 with one in which a point mutation (CTC to CGC) results in the amino acid substitution of of leucine to arginine at position 648 (L648R). Flp-mediated recombination removed the selection cassette. (J:321636)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Lmna Mutation: 84 strains or lines available

References

• Original: J:321636 Wang Y, et al., Abolishing the prelamin A ZMPSTE24 cleavage site leads to progeroid phenotypes with near-normal longevity in mice. Proc Natl Acad Sci U S A. 2022 Mar 1;119(9):e2118695119
• All: 1 reference(s)