Scn2a^em1.1Tvgn
Endonuclease-mediated Allele Detail

Summary

• Symbol: Scn2a^em1.1Tvgn
• Name: sodium channel, voltage-gated, type II, alpha; endonuclease-mediated mutation 1.1, TransViragen
• MGI ID: MGI:6887952
• Synonyms: SCN2A^fl
• Gene: Scn2a Location: Chr2:65451115-65597791 bp, + strand Genetic Position: Chr2, 38.61 cM
• Alliance: Scn2a^em1.1Tvgn page

Mutation origin

• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: CRISPR-targeting floxed exons 3 through 6. Flp-mediated recombination removed an FRT-flanked hygromycin resistance cassette. (J:321530)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Scn2a Mutation: 94 strains or lines available

References

• Original: J:321530 Gould E, et al., SCN2A contributes to oligodendroglia excitability and development in the mammalian brain. Cell Rep. 2021 Sep 7;36(10):109653
• All: 2 reference(s)