Agbl5^tm1.2Ics
Targeted Allele Detail

Summary

• Symbol: Agbl5^tm1.2Ics
• Name: ATP/GTP binding protein-like 5; targeted mutation 1.2, Mouse Clinical Institute
• MGI ID: MGI:6887875
• Synonyms: Ccp5^-
• Gene: Agbl5 Location: Chr5:31046038-31064309 bp, + strand Genetic Position: Chr5, 16.9 cM
• Alliance: Agbl5^tm1.2Ics page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:271687
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exon 7 was flanked with a loxP site and a neomycin resistance cassette flanked by loxP and FRT sites. Flp-mediated recombination removed the FRT-flanked selection cassette, leaving exon 7 floxed. Cre-mediated recombination removed exon 7. (J:271687)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Agbl5 Mutation: 42 strains or lines available

References

• Original: J:271687 Giordano T, et al., Loss of the deglutamylase CCP5 perturbs multiple steps of spermatogenesis and leads to male infertility. J Cell Sci. 2019 Feb 7;132(3):jcs226951
• All: 1 reference(s)