Mbd2^em1Smoc
Endonuclease-mediated Allele Detail

Summary

• Symbol: Mbd2^em1Smoc
• Name: methyl-CpG binding domain protein 2; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
• MGI ID: MGI:6887662
• Synonyms: Mbd2^{em1(flox)Smoc}, MBD2^flox
• Gene: Mbd2 Location: Chr18:70701260-70759202 bp, + strand Genetic Position: Chr18, 44.54 cM
• Alliance: Mbd2^em1Smoc page

Mutation origin

• Strain of Origin: C57BL/6JSmoc

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready)
• Mutation: Insertion
• CRISPR/Cas9 technology inserted loxP sites to flank target exons. (J:238766, J:321587)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mbd2 Mutation: 21 strains or lines available

References

• Original: J:321587 Ai K, et al., Methyl-CpG-binding domain protein 2 contributes to renal fibrosis through promoting polarized M1 macrophages. Cell Death Dis. 2022 Feb 8;13(2):125
• All: 2 reference(s)