Trpv3^tm1.1Cya
Targeted Allele Detail

Summary

• Symbol: Trpv3^tm1.1Cya
• Name: transient receptor potential cation channel, subfamily V, member 3; targeted mutation 1.1, Cyagen Biosciences
• MGI ID: MGI:6885980
• Synonyms: Trpv3^tm1.1Cgen
• Gene: Trpv3 Location: Chr11:73158315-73191194 bp, + strand Genetic Position: Chr11, 45.25 cM
• Alliance: Trpv3^tm1.1Cya page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:320995
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutations: Insertion, Single point mutation
• Mutation details: The targeting vector introduced a G to T mutation in exon 3 that results in the amino acid substitution of glycine with valine at position 568 (G568V). Cre-mediated recombination removed the neomycin resistance cassette. (J:320995)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trpv3 Mutation: 56 strains or lines available

References

• Original: J:320995 Song Z, et al., Hair Loss Caused by Gain-of-Function Mutant TRPV3 Is Associated with Premature Differentiation of Follicular Keratinocytes. J Invest Dermatol. 2021 Aug;141(8):1964-1974
• All: 1 reference(s)