Scn1a^tm1Gcol
Targeted Allele Detail

Summary

• Symbol: Scn1a^tm1Gcol
• Name: sodium channel, voltage-gated, type I, alpha; targeted mutation 1, Gaia Colasante
• MGI ID: MGI:6885842
• Synonyms: Scn1a^Stop
• Gene: Scn1a Location: Chr2:66101125-66271181 bp, - strand Genetic Position: Chr2, 39.13 cM
• Alliance: Scn1a^tm1Gcol page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:321347
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• A STOP cassette flanked by loxP sites was inserted in the intron between exons 6 and 7. (J:321347)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Scn1a Mutation: 113 strains or lines available

References

• Original: J:321347 Valassina N, et al., Scn1a gene reactivation after symptom onset rescues pathological phenotypes in a mouse model of Dravet syndrome. Nat Commun. 2022 Jan 10;13(1):161
• All: 1 reference(s)