Nnt^em1Asuh
Endonuclease-mediated Allele Detail

Summary

• Symbol: Nnt^em1Asuh
• Name: nicotinamide nucleotide transhydrogenase; endonuclease-mediated mutation 1, Andreas Suhrbier
• MGI ID: MGI:6885566
• Synonyms: C57BL/6N^deltaNnt8-12
• Gene: Nnt Location: Chr13:119472063-119545793 bp, - strand Genetic Position: Chr13, 67.21 cM, cytoband D2
• Alliance: Nnt^em1Asuh page

Mutation origin

• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR-targeting deleted 19,358 bp including exons 8 through 12 of 22 exons (mm10). This allele mimics the deletion found in C57BL/6J mice. (J:321166)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Nnt Mutation: 62 strains or lines available

References

• Original: J:321166 Rawle DJ, et al., Widespread discrepancy in Nnt genotypes and genetic backgrounds complicates granzyme A and other knockout mouse studies. Elife. 2022 Feb 4;11:e70207
• All: 1 reference(s)