Gzma^em1Asuh
Endonuclease-mediated Allele Detail

Summary

• Symbol: Gzma^em1Asuh
• Name: granzyme A; endonuclease-mediated mutation 1, Andreas Suhrbier
• MGI ID: MGI:6885562
• Synonyms: Gzma^S211A
• Gene: Gzma Location: Chr13:113230359-113237515 bp, - strand Genetic Position: Chr13, 63.93 cM, cytoband D
• Alliance: Gzma^em1Asuh page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Single point mutation
• Mutation details: CRISPR-targeting introduced the mutation that produces the amino acid substitution of serine to alanine at position 211 (S211A). (J:321166)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gzma Mutation: 37 strains or lines available

References

• Original: J:321166 Rawle DJ, et al., Widespread discrepancy in Nnt genotypes and genetic backgrounds complicates granzyme A and other knockout mouse studies. Elife. 2022 Feb 4;11:e70207
• All: 1 reference(s)