Mvp^tm1.1Smoc
Targeted Allele Detail

Summary

• Symbol: Mvp^tm1.1Smoc
• Name: major vault protein; targeted mutation 1.1, Shanghai Model Organisms Center
• MGI ID: MGI:6885542
• Synonyms: MVP^flox
• Gene: Mvp Location: Chr7:126586036-126613729 bp, - strand Genetic Position: Chr7, 69.26 cM, cytoband F4
• Alliance: Mvp^tm1.1Smoc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:275578
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: The targetted vector inserted a neomycin selection cassette flanked by two Frt sites, a loxP site into the upstream of exon 2 of the Mvp gene. Another loxP site was inserted downstream of exon 3. The resulted mice were crossbred with flp-recombinase mice to remove the neomycin cassette. (J:275578)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mvp Mutation: 62 strains or lines available

References

• Original: J:275578 Ben J, et al., Major vault protein suppresses obesity and atherosclerosis through inhibiting IKK-NF-kappaB signaling mediated inflammation. Nat Commun. 2019 Apr 17;10(1):1801
• All: 3 reference(s)