Bub1b^tm1Lmfv
Targeted Allele Detail

Summary

• Symbol: Bub1b^tm1Lmfv
• Name: BUB1B, mitotic checkpoint serine/threonine kinase; targeted mutation 1, Lev M Fedorov
• MGI ID: MGI:6881740
• Gene: Bub1b Location: Chr2:118428692-118472072 bp, + strand Genetic Position: Chr2, 59.4 cM
• Alliance: Bub1b^tm1Lmfv page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:316480
• Parent Cell Line: WW6 (ES Cell)
• Strain of Origin: STOCK 129/Sv and C57BL/6J and SJL

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• The targeting construct replaced exon 2 with a hygromycin resistance cassette. (J:316480)

Expression

In Mice Carrying this Mutation:

4 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bub1b Mutation: 57 strains or lines available

References

• Original: J:316480 Schmid M, et al., Mosaic variegated aneuploidy in mouse BubR1 deficient embryos and pregnancy loss in human. Chromosome Res. 2014 Sep;22(3):375-92
• All: 1 reference(s)