Tmem219^em1Pfio
Endonuclease-mediated Allele Detail

Summary

• Symbol: Tmem219^em1Pfio
• Name: transmembrane protein 219; endonuclease-mediated mutation 1, Paolo Fiorina
• MGI ID: MGI:6881737
• Synonyms: TMEM219^fl, TMEM219^flox
• Gene: Tmem219 Location: Chr7:126485343-126522089 bp, - strand Genetic Position: Chr7, 69.25 cM, cytoband F4
• Alliance: Tmem219^em1Pfio page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready)
• Mutation: Insertion
• Exons 2 and 3 were flanked by loxP sites using CRISPR/Cas9 technology. (J:320836)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tmem219 Mutation: 9 strains or lines available

References

• Original: J:320836 D'Addio F, et al., The IGFBP3/TMEM219 pathway regulates beta cell homeostasis. Nat Commun. 2022 Feb 3;13(1):684
• All: 2 reference(s)