Gpr180^em1Wfrm
Endonuclease-mediated Allele Detail

Summary

• Symbol: Gpr180^em1Wfrm
• Name: G protein-coupled receptor 180; endonuclease-mediated mutation 1, Christian Wolfrum
• MGI ID: MGI:6872321
• Gene: Gpr180 Location: Chr14:118374570-118400673 bp, + strand Genetic Position: Chr14, 61.78 cM, cytoband E4
• Alliance: Gpr180^em1Wfrm page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Not Specified
• CRISPR-targeting of exon 3 created a loxP site. (J:320361)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gpr180 Mutation: 25 strains or lines available

References

• Original: J:320361 Balazova L, et al., GPR180 is a component of TGFbeta signalling that promotes thermogenic adipocyte function and mediates the metabolic effects of the adipocyte-secreted factor CTHRC1. Nat Commun. 2021 Dec 8;12(1):7144
• All: 1 reference(s)