Cavin2^tm1.1Smat
Targeted Allele Detail

Summary

• Symbol: Cavin2^tm1.1Smat
• Name: caveolae associated 2; targeted mutation 1.1, Satoaki Matoba
• MGI ID: MGI:6871012
• Synonyms: Cavin-2^fl
• Gene: Cavin2 Location: Chr1:51328285-51342119 bp, + strand Genetic Position: Chr1, 26.13 cM
• Alliance: Cavin2^tm1.1Smat page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:318731
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The targeting vector inserted a loxP site upstream of the coding sequence in the first coding exon and an FRT-flanked neomycin resistance cassette with a 3 prime loxP site. Flp-mediated recombination removed the selection cassette. (J:318731)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cavin2 Mutation: 21 strains or lines available

References

• Original: J:318731 Higuchi Y, et al., Requirement of Cavin-2 for the expression and stability of IRbeta in adequate adipocyte differentiation. Mol Metab. 2022 Jan;55:101416
• All: 1 reference(s)