Rr114^tm1.1Tshir
Targeted Allele Detail

Summary

• Symbol: Rr114^tm1.1Tshir
• Name: regulatory region 114; targeted mutation 1.1, Toshihiko Shiroishi
• MGI ID: MGI:6870534
• Synonyms: deltaMRCS1, MRCS1^-
• Gene: Rr114 Location: Chr5:29290873-29291545 bp Genetic Position: Chr5, Syntenic
• Alliance: Rr114^tm1.1Tshir page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:320178
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Modified regulatory region)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 673-bp (chr5:29085875-29086547, GRCm38/mm10) fragment that includes Shh enhancer MRCS1 (mammals-reptiles conserved sequence 1) was replaced with a loxP site flanked neomycin resistance gene cassette. The neo cassette was removed through subsequent cre-mediated recombination. (J:320178)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rr114 Mutation: 0 strains or lines available

Notes

Riken Laboratory for Animal Resources and Genetic Engineering mouse line CDB0781K.

References

• Original: J:320178 Sagai T, et al., SHH signaling directed by two oral epithelium-specific enhancers controls tooth and oral development. Sci Rep. 2017 Oct 11;7(1):13004
• All: 1 reference(s)