Wdr81^em1Curie
Endonuclease-mediated Allele Detail

Summary

• Symbol: Wdr81^em1Curie
• Name: WD repeat domain 81; endonuclease-mediated mutation 1, Institut Curie
• MGI ID: MGI:6870512
• Gene: Wdr81 Location: Chr11:75331770-75345543 bp, - strand Genetic Position: Chr11, 45.89 cM
• Alliance: Wdr81^em1Curie page

Mutation origin

• Strain of Origin: (C57BL/6J x DBA/2J)F1

Mutation description

• Allele Type: Endonuclease-mediated (Modified isoform(s))
• Mutation: Intragenic deletion
• CRISPR-targeting removed the portion of exon 1 present in isoform 1. Isoform 2 is not altered. (J:318768)

Expression

In Mice Carrying this Mutation:

21 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Wdr81 Mutation: 56 strains or lines available

References

• Original: J:318768 Carpentieri JA, et al., Endosomal trafficking defects alter neural progenitor proliferation and cause microcephaly. Nat Commun. 2022 Jan 10;13(1):16
• All: 1 reference(s)