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Supt5tm1.1Rrp
Targeted Allele Detail
Summary
Symbol: Supt5tm1.1Rrp
Name: suppressor of Ty 5, DSIF elongation factor subunit; targeted mutation 1.1, Rushad Pavri
MGI ID: MGI:6867017
Synonyms: Supt5hFl
Gene: Supt5  Location: Chr7:28014316-28038171 bp, - strand  Genetic Position: Chr7, 16.68 cM
Alliance: Supt5tm1.1Rrp page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:319843
Parent Cell Line:  CY2.4 (ES Cell)
Strain of Origin:  B6(Cg)-Tyrc-2J
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsThe targeting construct inserted upstream of exon 14 an FRT site, lacZ reporter gene, loxP site, neomycin resistance cassette, FRT site, and loxP site. It also inserted downstream of exon 16. Flp-mediated recombination removed the reporter and selection cassette, leaving exons 14 through 16 floxed. (J:319843)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Supt5 Mutation:  58 strains or lines available
References
Original:  J:319843 Fitz J, et al., Regulation of RNA polymerase II processivity by Spt5 is restricted to a narrow window during elongation. EMBO J. 2018 Apr 13;37(8)
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
06/12/2024
MGI 6.13
The Jackson Laboratory