Supt5^tm1.1Rrp
Targeted Allele Detail

Summary

• Symbol: Supt5^tm1.1Rrp
• Name: suppressor of Ty 5, DSIF elongation factor subunit; targeted mutation 1.1, Rushad Pavri
• MGI ID: MGI:6867017
• Synonyms: Supt5h^Fl
• Gene: Supt5 Location: Chr7:28014316-28038171 bp, - strand Genetic Position: Chr7, 16.68 cM
• Alliance: Supt5^tm1.1Rrp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:319843
• Parent Cell Line: CY2.4 (ES Cell)
• Strain of Origin: B6(Cg)-Tyr^c-2J

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The targeting construct inserted upstream of exon 14 an FRT site, lacZ reporter gene, loxP site, neomycin resistance cassette, FRT site, and loxP site. It also inserted downstream of exon 16. Flp-mediated recombination removed the reporter and selection cassette, leaving exons 14 through 16 floxed. (J:319843)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Supt5 Mutation: 58 strains or lines available

References

• Original: J:319843 Fitz J, et al., Regulation of RNA polymerase II processivity by Spt5 is restricted to a narrow window during elongation. EMBO J. 2018 Apr 13;37(8)
• All: 2 reference(s)