Brd4^em1Gpt
Endonuclease-mediated Allele Detail

Summary

• Symbol: Brd4^em1Gpt
• Name: bromodomain containing 4; endonuclease-mediated mutation 1, GemPharmatech, Co., Ltd
• MGI ID: MGI:6866940
• Synonyms: Brd4^em1Cflox, Brd4^flox
• Gene: Brd4 Location: Chr17:32415248-32503696 bp, - strand Genetic Position: Chr17, 17.39 cM, cytoband B2
• Alliance: Brd4^em1Gpt page

Mutation origin

• Strain of Origin: C57BL/6JGpt

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready)
• Mutation: Insertion
• Exon 5 was flanked by loxP sites using CRISPR/Cas9 technology. (J:319877)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Brd4 Mutation: 110 strains or lines available

References

• Original: J:319877 Zeng S, et al., The suppression of Brd4 inhibits peripheral plasma cell differentiation and exhibits therapeutic potential for systemic lupus erythematosus. Int Immunopharmacol. 2022 Feb;103:108498
• All: 1 reference(s)