Cxcr2^{tm1(CXCR2)Rale}
Targeted Allele Detail

Summary

• Symbol: Cxcr2^{tm1(CXCR2)Rale}
• Name: C-X-C motif chemokine receptor 2; targeted mutation 1, Richard A Lerner
• MGI ID: MGI:6865788
• Synonyms: hCXCR2
• Gene: Cxcr2 Location: Chr1:74193153-74200405 bp, + strand Genetic Position: Chr1, 38.41 cM
• Alliance: Cxcr2^{tm1(CXCR2)Rale} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:319853
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Humanized sequence, Inserted expressed sequence)
• Mutations: Insertion, Intragenic deletion
• Cxcr2^{tm1(CXCR2)Rale} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  CXCR2 (3579)

  Cxcr2

  (MGI:105303)

• Mutation details: The mouse Cxcr2 coding sequence was replaced with the human CXCR2 coding DNA sequence via homologous recombination. (J:319853)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cxcr2 Mutation: 32 strains or lines available

References

• Original: J:319853 Shi X, et al., Selection of a picomolar antibody that targets CXCR2-mediated neutrophil activation and alleviates EAE symptoms. Nat Commun. 2021 May 5;12(1):2547
• All: 1 reference(s)