Minpp1^em1Vca
Endonuclease-mediated Allele Detail

Summary

• Symbol: Minpp1^em1Vca
• Name: multiple inositol polyphosphate histidine phosphatase 1; endonuclease-mediated mutation 1, Vincent Cantagrel
• MGI ID: MGI:6865735
• Gene: Minpp1 Location: Chr19:32463169-32492764 bp, + strand Genetic Position: Chr19, 27.25 cM
• Alliance: Minpp1^em1Vca page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR/Cas9 technology generated a 31 bp deletion in exon 1. (J:299426)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Minpp1 Mutation: 10 strains or lines available

References

• Original: J:299426 Ucuncu E, et al., MINPP1 prevents intracellular accumulation of the chelator inositol hexakisphosphate and is mutated in Pontocerebellar Hypoplasia. Nat Commun. 2020 Nov 30;11(1):6087
• All: 1 reference(s)