Gabbr1^em1Kvp
Endonuclease-mediated Allele Detail

Summary

• Symbol: Gabbr1^em1Kvp
• Name: gamma-aminobutyric acid type B receptor subunit 1; endonuclease-mediated mutation 1, Kostandin V Pajcini
• MGI ID: MGI:6865722
• Synonyms: Gabbr1^em59
• Gene: Gabbr1 Location: Chr17:37356888-37385197 bp, + strand Genetic Position: Chr17, 19.16 cM
• Alliance: Gabbr1^em1Kvp page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Insertion
• Mutation details: CRISPR/Cas9 technology generated a 1-bp adenine insertion in exon 5 resulting in a nonsense mutation. (J:303802)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gabbr1 Mutation: 74 strains or lines available

References

• Original: J:303802 Shao L, et al., The neurotransmitter receptor Gabbr1 regulates proliferation and function of hematopoietic stem and progenitor cells. Blood. 2021 Feb 11;137(6):775-787
• All: 1 reference(s)