Ace2^em4Lutzy
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ace2^em4Lutzy
• Name: angiotensin converting enzyme 2; endonuclease-mediated mutation 4, Cathleen Lutz
• MGI ID: MGI:6865646
• Synonyms: Ace2^H353K
• Gene: Ace2 Location: ChrX:162922338-162971414 bp, + strand Genetic Position: ChrX, 76.12 cM, cytoband F5
• Alliance: Ace2^em4Lutzy page

Mutation origin

• Strain of Origin: B6.Cg-Fcgrt^tm1Dcr Tg(FCGRT)32Dcr/DcrJ

Mutation description

• Allele Type: Endonuclease-mediated (Humanized sequence)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: CRISPR/cas9 genome editing was used to create an amino acid substitution at position 353 (histidine to lysine, H353K). A lysine is present at position 353 of ACE2 in humans, non-human primates, bats and ferrets, while mice and rats have a histidine at this position. (J:101977)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ace2 Mutation: 54 strains or lines available

References

• Original: J:101977 The Jackson Laboratory, Information obtained from The Jackson Laboratory, Bar Harbor, ME. Unpublished. 2005-2017
• All: 1 reference(s)