Npr2^em1.1Kuhn
Endonuclease-mediated Allele Detail

Summary

• Symbol: Npr2^em1.1Kuhn
• Name: natriuretic peptide receptor 2; endonuclease-mediated mutation 1.1, Michaela Kuhn
• MGI ID: MGI:6864463
• Synonyms: Npr2^flox
• Gene: Npr2 Location: Chr4:43631935-43651244 bp, + strand Genetic Position: Chr4, 23.05 cM
• Alliance: Npr2^em1.1Kuhn page

Mutation origin

• Strain of Origin: 129/Sv x C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready)
• Mutation: Insertion
• Mutation details: TALEN-targeting with donor plasmids inserted loxP sites flanking exon 7 and an FRT-flanked neomycin selection cassette in intron 6. Flp-mediated recombination removed the selection cassette. (J:279999)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Npr2 Mutation: 63 strains or lines available

References

• Original: J:279999 Spiranec K, et al., Endothelial C-Type Natriuretic Peptide Acts on Pericytes to Regulate Microcirculatory Flow and Blood Pressure. Circulation. 2018 Jul 31;138(5):494-508
• All: 4 reference(s)