Sgms1^tm2.1Jia
Targeted Allele Detail

Summary

• Symbol: Sgms1^tm2.1Jia
• Name: sphingomyelin synthase 1; targeted mutation 2.1, Xian-Cheng Jiang
• MGI ID: MGI:6864444
• Gene: Sgms1 Location: Chr19:32100127-32367114 bp, - strand Genetic Position: Chr19, 26.68 cM
• Alliance: Sgms1^tm2.1Jia page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:319442
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The targeting construct introduced a loxP- and FRT-flanked neomycin resistance cassette into intron 7 and a single loxP site upstream of exon 6. Flp-mediated recombination removed the selection cassette and left exon 6 floxed. (J:319442)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sgms1 Mutation: 228 strains or lines available

References

• Original: J:319442 Li Z, et al., Effect of liver total sphingomyelin synthase deficiency on plasma lipid metabolism. Biochim Biophys Acta Mol Cell Biol Lipids. 2021 May;1866(5):158898
• All: 4 reference(s)