Tg(EEF1A1-IL15)K2Sidub
Transgene Detail

Summary

• Symbol: Tg(EEF1A1-IL15)K2Sidub
• Name: transgene insertion K2, Sigrid Dubois
• MGI ID: MGI:6864331
• Synonyms: IL-15Tg
• Transgene: Tg(EEF1A1-IL15)K2Sidub Location: unknown
• Alliance: Tg(EEF1A1-IL15)K2Sidub page

Transgene origin

• Strain of Origin: 129

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(EEF1A1-IL15)K2Sidub expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  IL15 (3600)

  Il15	(MGI:103014)

• Mutation details: The IL-15Tg transgenic construct contains from 5' to 3'; a human EEF1A1 (eukaryotic translation elongation factor 1 alpha 1) promoter, a bovine preprolactin signal peptide, the human IL15 (interleukin 15) mature coding sequence followed by an SV40 polyA signal. . Founder line K2 expressed the highest amount of IL15 (650-800 pg/ml, 40-65 pM). (J:65262)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:65262 Marks-Konczalik J, et al., IL-2-induced activation-induced cell death is inhibited in IL-15 transgenic mice. Proc Natl Acad Sci U S A. 2000 Oct 10;97(21):11445-50
• All: 2 reference(s)