Ccnd3^em1Vic
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ccnd3^em1Vic
• Name: cyclin D3; endonuclease-mediated mutation 1, Gabriel Victora
• MGI ID: MGI:6864288
• Synonyms: Ccnd3^T283A
• Gene: Ccnd3 Location: Chr17:47815976-47910614 bp, + strand Genetic Position: Chr17, 23.37 cM
• Alliance: Ccnd3^em1Vic page

Mutation origin

• Strain of Origin: (C57BL/6 x SJL)F1

Mutation description

• Allele Type: Endonuclease-mediated (Not Applicable)
• Mutation: Single point mutation
• Mutation details: CRISPR/Cas9 technology generated an A to G change resulting in a threonine to alanine substitution at amino acid 283 (p.T283A) in exon 7. This mutation prevents phosphorylation of T283. (J:307801)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ccnd3 Mutation: 506 strains or lines available

References

• Original: J:307801 Pae J, et al., Cyclin D3 drives inertial cell cycling in dark zone germinal center B cells. J Exp Med. 2021 Apr 5;218(4)
• All: 2 reference(s)