Rpgr^tm2.1Stie
Targeted Allele Detail

Summary

• Symbol: Rpgr^tm2.1Stie
• Name: retinitis pigmentosa GTPase regulator; targeted mutation 2.1, Knut Stieger
• MGI ID: MGI:6864283
• Synonyms: RPGR^ORF15
• Gene: Rpgr Location: ChrX:10024455-10083034 bp, - strand Genetic Position: ChrX, 4.62 cM
• Alliance: Rpgr^tm2.1Stie page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:319445
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6 x 129

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutation: Nucleotide substitutions
• Mutation details: The targeting construct inserted four mutations including: a T to C in ORF15 (introduces an XbaI site), single A deletion in ORF15 (pathologic frame shift), A to T in ORF15 (removal of stop codon), and 6 bp deletion downstream of ORF15 (introduces I-SceI site). The EEGEGE repeats are changed to a ERKXGR repeat profile. Cre-mediated recombination removed the floxed neomycin resistance cassette. (J:319445)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rpgr Mutation: 12 strains or lines available

References

• Original: J:319445 Schlegel J, et al., Toward genome editing in X-linked RP-development of a mouse model with specific treatment relevant features. Transl Res. 2019 Jan;203:57-72
• All: 1 reference(s)