Wnt1^tm1.1Hhtg
Targeted Allele Detail

Summary

• Symbol: Wnt1^tm1.1Hhtg
• Name: wingless-type MMTV integration site family, member 1; targeted mutation 1.1, Irm Hermans-Borgmeyer
• MGI ID: MGI:6864073
• Synonyms: Wnt1^R235W
• Gene: Wnt1 Location: Chr15:98687738-98691711 bp, + strand Genetic Position: Chr15, 54.65 cM, cytoband F1-F3
• Alliance: Wnt1^tm1.1Hhtg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:319363
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutation: Single point mutation
• Mutation details: The targeting construct inserted the point mutation C to T generating the amino acid substitution of arginine with tryptophan at position 235 (R235W). Flp-mediated recombination removed the selection cassette. (J:319363)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Wnt1 Mutation: 29 strains or lines available

References

• Original: J:319363 Yorgan TA, et al., Mice Carrying a Ubiquitous R235W Mutation of Wnt1 Display a Bone-Specific Phenotype. J Bone Miner Res. 2020;35(9):1726-1737
• All: 1 reference(s)