Tnfsf18^tm1.1Etms
Targeted Allele Detail

Summary

• Symbol: Tnfsf18^tm1.1Etms
• Name: tumor necrosis factor (ligand) superfamily, member 18; targeted mutation 1.1, Ethan M Shevach
• MGI ID: MGI:6863887
• Synonyms: Tnfsf18^exon2fl
• Gene: Tnfsf18 Location: Chr1:161322224-161332859 bp, + strand Genetic Position: Chr1, 69.75 cM
• Alliance: Tnfsf18^tm1.1Etms page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:253563
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: LoxP sites were inserted to flank exon 2. An adjacent frt-flanked neomycin selection cassette was removed via Flp-mediated recombination in the germline. (J:253563)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tnfsf18 Mutation: 17 strains or lines available

References

• Original: J:253563 Chang YH, et al., Dichotomous Expression of TNF Superfamily Ligands on Antigen-Presenting Cells Controls Post-priming Anti-viral CD4(+) T Cell Immunity. Immunity. 2017 Nov 21;47(5):943-958.e9
• All: 2 reference(s)