Rnf2^tm1.1Krai
Targeted Allele Detail

Summary

• Symbol: Rnf2^tm1.1Krai
• Name: ring finger protein 2; targeted mutation 1, Kunal Rai
• MGI ID: MGI:6860507
• Synonyms: Rnf2^flox, RNF2^L
• Gene: Rnf2 Location: Chr1:151345159-151376562 bp, - strand Genetic Position: Chr1, 64.15 cM
• Alliance: Rnf2^tm1.1Krai page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:231490
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The targeting construct inserted upstream of exon 2 a loxP site and downstream of exon 2 an FRT-flanked neomycin resistance cassette and loxP site. Flp-mediated recombination removed the selection cassette. (J:231490)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rnf2 Mutation: 35 strains or lines available

References

• Original: J:231490 Rai K, et al., Dual Roles of RNF2 in Melanoma Progression. Cancer Discov. 2015 Dec;5(12):1314-27
• All: 1 reference(s)