Suz12^tm1.1Mag
Targeted Allele Detail

Summary

• Symbol: Suz12^tm1.1Mag
• Name: SUZ12 polycomb repressive complex 2 subunit; targeted mutation 1.1, Terry Magnuson
• MGI ID: MGI:6858079
• Gene: Suz12 Location: Chr11:79883932-79924949 bp, + strand Genetic Position: Chr11, 47.36 cM
• Alliance: Suz12^tm1.1Mag page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:213769
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An FRT flanked neo cassette and loxP site were inserted upstream of exon 2 and a loxP site was inserted downstream of exon 3 via homologous recombination. Flp-mediated recombination removed the selection cassette. (J:213769)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Suz12 Mutation: 60 strains or lines available

References

• Original: J:213769 Mu W, et al., Repression of the soma-specific transcriptome by Polycomb-repressive complex 2 promotes male germ cell development. Genes Dev. 2014 Sep 15;28(18):2056-69
• All: 1 reference(s)