Fdps^tm1Jiy
Targeted Allele Detail

Summary

• Symbol: Fdps^tm1Jiy
• Name: farnesyl diphosphate synthetase; targeted mutation 1, Jian Yang
• MGI ID: MGI:6857767
• Synonyms: Fdps LoxP
• Gene: Fdps Location: Chr3:89000895-89009266 bp, - strand Genetic Position: Chr3, 39.01 cM
• Alliance: Fdps^tm1Jiy page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:317808
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: Exons 2 and 3 were flanked by loxP sites. An FRT-flanked neomycin selection cassette was inserted upstream of the first loxP site. (J:317808)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fdps Mutation: 28 strains or lines available

References

• Original: J:317808 Wang X, et al., Cardiac-specific deletion of FDPS induces cardiac remodeling and dysfunction by enhancing the activity of small GTP-binding proteins. J Pathol. 2021 Dec;255(4):438-450
• All: 1 reference(s)