Tg(Col1a1-Sost)1Hhtg
Transgene Detail

Summary

• Symbol: Tg(Col1a1-Sost)1Hhtg
• Name: transgene insertion 1, Irm Hermans-Borgmeyer
• MGI ID: MGI:6857637
• Transgene: Tg(Col1a1-Sost)1Hhtg Location: unknown
• Alliance: Tg(Col1a1-Sost)1Hhtg page

Transgene origin

• Strain of Origin: (C57BL/6J x CBA)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Col1a1-Sost)1Hhtg expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Sost (MGI:1921749)

• Mutation details: The transgene contains the 2.3 kb of the mouse promoter driving osteoblast-specific expression of the open reading frame. One founder was generated. (J:233348)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:233348 Yorgan TA, et al., The Anti-Osteoanabolic Function of Sclerostin Is Blunted in Mice Carrying a High Bone Mass Mutation of Lrp5. J Bone Miner Res. 2015 Jul;30(7):1175-83
• All: 1 reference(s)