Dyrk2^em#Kyos
Endonuclease-mediated Allele Detail

Summary

• Symbol: Dyrk2^em#Kyos
• Name: dual-specificity tyrosine phosphorylation regulated kinase 2; endonuclease-mediated mutation, Kiyotsugu Yoshida
• MGI ID: MGI:6856780
• Synonyms: Dyrk2^-
• Gene: Dyrk2 Location: Chr10:118691508-118706114 bp, - strand Genetic Position: Chr10, 66.75 cM
• Alliance: Dyrk2^em#Kyos page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR-targeting of exon 3 produced three deletion alleles: a 32-bp deletion, a 19-bp deletion, and a 34-bp deletion. The pound symbol is used because the lines are pooled. Western blot analysis confirmed absence of protein in E18.5 embryos, while the expression levels of other Dyrk family members are unchanged. (J:312414)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dyrk2 Mutation: 32 strains or lines available

References

• Original: J:312414 Yogosawa S, et al., Mice lacking DYRK2 exhibit congenital malformations with lung hypoplasia and altered Foxf1 expression gradient. Commun Biol. 2021 Oct 20;4(1):1204
• All: 1 reference(s)