Gt(ROSA)26Sor^{tm1(Il7r*)Draw}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1(Il7r*)Draw}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, David Rawlings
• MGI ID: MGI:6856711
• Synonyms: aIL7R, Rosa26-aIL7R⁺
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1(Il7r*)Draw} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:317339
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Targeted (Conditional ready, Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Mutation details: A loxP-flanked Neo-3x-stop cassette, murine Il7r containing the B-cell acute lymphoblastic leukemia (B-ALL)-associated activating P243insPPCL mutation, and a self-cleaving T2A-linked GFP reporter were inserted into the locus. The P243insPPCL mutation is an in-frame insertion of four amino acids; proline, proline, cysteine, and leucine at the position 243 proline. (J:317339)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1089 strains or lines available

References

• Original: J:317339 Thomas KR, et al., Activated interleukin-7 receptor signaling drives B-cell acute lymphoblastic leukemia in mice. Leukemia. 2022 Jan;36(1):42-57
• All: 1 reference(s)