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Endonuclease-mediated Allele Detail
Symbol: Dpp4em1(DPP4)Mbp
Name: dipeptidylpeptidase 4; endonuclease-mediated mutation 1, Mouse Biology Program, UC Davis
MGI ID: MGI:6856706
Gene: Dpp4  Location: Chr2:62160417-62242575 bp, - strand  Genetic Position: Chr2, 35.85 cM, cytoband C2-D
Alliance: Dpp4em1(DPP4)Mbp page
Strain of Origin:  C57BL/6NCrl
Allele Type:    Endonuclease-mediated (Inserted expressed sequence, Null/knockout)
Mutations:    Insertion, Intragenic deletion
Dpp4em1(DPP4)Mbp expresses 1 gene
Mutation detailsCRISPR-targeting inserted exons 2-26 of human DPP4 in-frame into exon 2 of the mouse gene. The insert contains four silent mutations in the coding sequence to prevent CRISPR RNP re-cleavage (see HGVS nomenclature below); it uses the human 3' UTR to terminate transcription and to prevent potential downstream splicing or RNP re-cleavage. (J:94077)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Dpp4 Mutation:  51 strains or lines available
Original:  J:94077 Mutant Mouse Regional Resource Centers, Information obtained from the Mutant Mouse Regional Resource Centers (MMRRC). Unpublished. 2004-2015;
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory